Cancer research results and successful cases of Cryoablation

Cryoablation for Cancer reaseach base on 8000 cases in,reported in 5th Int Forum on Cancer treatment Guangzhou, China Jul 2 2016,edited by Dr,Kecheng Xu.

Why do we use cryoablation?

Tumor ablation is more important to aim at Prolong survival period and improve quality of life.

Cancer is a chronic disease which can be controlled.Ablation is one of the most effective means to control progressive parenchyma tumor.

Cryosurgery is a novel technique for treatment of cancer which has been approved by the United States~ Food & Drug Administration (FDA) in 1998 and China~s SFDA in 1999.Fuda Cancer Hospital-Guangzhou has used the technique since 2000. To date, Fuda has the greatest amount of experience in this minimally invasive operation; often Fuda trains doctors from around the world on the cryosurgery technique. And number of cryosurgery cases has nearly topped 8,000 cases with a variety of malignant tumors (more than 34 different kinds of cancers).  At the same time, Combined the new idea of " 3C+P" (Cryoablation, Combined immunotherapy,  Cancer mincrosphere intervention, Personalized therapy) treatment model has been successful to apply to treat  a variety of cancers too, 

In the latest edition of NCCN guidelines, cryoablation has been recommended for unresectable cancers.  For example: 

Cryoablation is an local regional therapy for Hepatocellular Carcinoma (HCC)

cryo-therapy is a preferred local treatment modality  in Surgical therapy for Non-small Cell Lung Cancer.

Ablation techniques can be considered when   Colon cancer have been metastases

Use of cryoablation in Fuda

1.“Radical” eradication of “small” cancer

2.“Debulky” for unresectable tumors

3.Freezing-assisted operation 

1.To alleviate pain caused by tumor

8000 patients treated by cryoablation in Fuda

Two types of cryosurgical equipment designed to use in Fuda 

Percutaneous cryoablation under CT or US

No.1  “Radical” eradication

Those patients who cannot undergo operation due to weak condition or co-morbidity, and those who refuse to receive operation, percutaneous cryoablation is to achieve great efficacy for cancer and even get cancer cured.

Unresectable, metastases on operation, no response on chemo/radio and recurrent advanced cancer

            

What Kind Of Cancers Do The Cryoablation Can Treat?

What is percutaneous cryoablation?

In percutaneous cryoablation, no large incisions are made. Instead, an interventional radiologist inserts a thin, needle-like probe through the skin and into the tumor, using advanced imaging technology for guidance. This technique helps avoid larger incisions that are associated with cryoablation during traditional open surgery or minimally invasive laparoscopic surgery.

How does cryoablation work?

Depending on the tumor's size, one or more probes are inserted into the tumor. Pressurized gas is pumped to a chamber at the needle's tip, where it expands then cools, creating an ice ball chilled to minus 160 degrees Celsius. The ice ball engulfs and destroys the tumor while sparing healthy tissue. Ultrathin sensor needles also are inserted at the tumor's margins to monitor temperatures and ensure that all the cancerous tissue is destroyed.

What kind of cancer do the cryoablation can treat?

Cryoablation is performed by using argon-helium system. Two to three cycles of the freezing/thawing are performed. The freezing continues until the "ice-ball" formed at the tip if the cryoprobe is large enough to cover tumor. A 5-10 mm margin of normal tissue is included in the freezing process. For larger tumors, multiple cryoprobes were used. In some cases, it may become necessary to perform at least 2-3 sessions of the cryoablation procedure. This is possible because the procedure is minimally invasive, and often does not require cutting. The probes are simply inserted through the skin and guided by real-time ultrasound.

Kidney cancer and bone metastases, pancreatic endocrine tumor, pancreatic cancer, retroperitoneal liposarcoma, “ dough figurine” retroperitoneal liposarcoma, non-small-cell lung cancer (NSCLC), melanoma, esophagus cancer, multiple neuroendocrine tumor, breast cancer, ovarian cancer, neck giant teratoma,  uterine Cancer, lymphoma , liver cancer, bone cancer, colon cancer, lung cancer, skin cancer and etc.